i would run carbon in it, thats it, and only with a heavy sps, or softie load, as for building a fuge, it can be done much easier and cheaper, but other than that, i dont see why not, just doesnt seem practical, as for running as a normal filter, it would be fine for a fish only, but a reef tank, it would be just too much work, if your into a lot of work and maintenance, go for it, if not, the skimmer actually pulls crud OUT of the water column.
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The meek shall inherit the Earth. Big deal. By the time they get it the rest of us will have messed it all up.
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