Not really.
They do up to a point, but then they start doing too much of the work and wind up hamstringing the ecofilter's efficiency. I would personally use one as a redundant backup, but it wouldn't be the best idea.
The ecofilters take a long time to mature when other filtration methods are also in use. Once they are fully mature, the other filters hardly make a dent in the overall system compared to the ecofilter, but the eco would still work better without the competition.
In a tank with lots of fish or with big fish, that is, a tank that gets a lot of food put into it, extra filtration & skimming are good to use. For tanks that are mostly invert and/or have only a few small fish, extra filtration is not really needed.
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