[redpaulhus]

Any "enclosed" filter that could handle that kind of waste load would need constant (daily?) maint to prevent massive nitrate problems (IMO).
You could buy 3-6 canister filters but I wouldn't see the point - its going to be hard to keep up with the cleaning - although alot depends on your bioload (types of fishes, etc).
Plus alot of the bigger skimmers either sit in or feed off of a sump (which was why Deltec and a few other german skimmers (turboflotor 5000) came to mind - you might be able to run them off of a Rainbow Lifeguard pressurised canister system...)
You may want to check out some of the systems used in commercial accounts (hotels, casinos, resturants, etc) for big public tanks - a large fluidized bed or sand filter might work, but the ones I've worked with were a pain to backflush (sand) or tricky after power outages (FB).